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Reporting and misreporting of sex differences in the biological

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Question 3: Were the data from males and females pooled for any of the analyses? In this study we included only articles in which data were  - Information from elifesciences.org

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Y chromosome functions in mammalian spermatogenesis eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

These sexratio skews likely result from differential fertilising abilities between X and Ybearing sperms in Sly and Slx/Slxl1 depleted models  - Information from elifesciences.org

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Early life adversity decreases preadolescent fear expression

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Early life adversity (ELA) accelerated PV+ interneuron development in BLA and delayed the ability of preadolescent mice to express  - Information from elifesciences.org

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TRex a fast multianimal tracking system with markerless

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

This machinelearningbased approach herein termed visual to conduct a twodimensional reconstruction of each individuals visual field  - Information from elifesciences.org

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Integration of light and metabolic signals for stem cell eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

s findings suggest that the activation of TOR by light allows plant this enzyme is able to act on WUSCHEL to trigger stem cell division - Information from elifesciences.org

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Anisotropic growth is achieved through the additive eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Anisotropic growth is common in plant organs and is canonically attributed to cell wall anisotropy produced by oriented cellulose fibers - Information from elifesciences.org

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A complete toolset for the study of Ustilago bromivora eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Among the facultative biotrophic pathogens the smut fungus Ustilago maydis is a valuable model to study biotrophic interactions (Djamei et  - Information from elifesciences.org

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Poor coherence in older peoples speech is explained eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Remaining focused on the topic at hand when speaking depends on effective selection of taskrelevant semantic knowledge and declines in  - Information from elifesciences.org

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Nomadiccolonial life strategies enable paradoxical survival

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

By modelling organisms that alternate between individual and Nomads and colonists may alternate behaviors in response to changes in the  - Information from elifesciences.org

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Impaired respiration elicits SrrABdependent programmed cell

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

At the same time the bacteria produce more of an enzyme that breaks down Increased biofilm formation and cell lysis is a programmed - Information from elifesciences.org

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Information flow cell types and stereotypy in a full eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs mapping olfactory  - Information from elifesciences.org

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Spinal signalling of Cfiber mediated pleasant touch in humans

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

thermal threshold and discriminative touch sensation testing in the precordotomy and postcordot omy states Significant differences (Related  - Information from elifesciences.org

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A stochastic neuronal model predicts random search eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Random search is an evolutionarily ancient set of foraging strategies that evolved as an adaptation to environments in which prey items are  - Information from elifesciences.org

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The East Asian gut microbiome is distinct from colocalized

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The gut microbiota of East Asians is distinct dissociated from body mass (2008) A core gut microbiome in obese and lean twins - Information from elifesciences.org

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An experimental test of the effects of redacting grant applicant

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Valerie Durrant is employed by NIH/CSR Bruce Reed NIH/Center for Scientific Review Bethesda United States For correspondence - Information from elifesciences.org

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Use of signals of positive and negative selection to distinguish

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A major goal of cancer genomics is to identify all genes that play advantage to tumor cells they are subject to positive selection  - Information from elifesciences.org

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Imaging neuropeptide release at synapses with a genetically

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In Drosophila a fusion between rat Atrial Natriuretic Peptide/Factor (ANP/F) and GFP was used to investigate neuropeptide trafficking at  - Information from elifesciences.org

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Alpha1 adrenergic receptor antagonists to prevent eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We previously demonstrated that alpha1 adrenergic receptor (⍺1AR) (2011) α1adrenergic receptors positively regulate Tolllike  - Information from elifesciences.org

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Structure of a bacterial ATP synthase eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Subunits of Bacillus PS3 ATP synthase including subunit β bearing an Similar integer step sizes were found in yeast ATP synthase - Information from elifesciences.org

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Translation affects mRNA stability in a codondependent

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Human mRNA decay correlates with codon composition in human cell lines To determine whether codon composition Ariel Alejandro Bazzini - Information from elifesciences.org

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A new class of disordered elements controls DNA replication

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A new class of disordered elements controls DNA replication through initiator selfassembly Bleichert F · Botchan MR · Berger JM - Information from elifesciences.org

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Convalescent COVID19 patients are susceptible to endothelial

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Louis LY Teo Fei Gao Ru San Tan Liang Zhong Angela S Koh The funders had no role in study design data collection and interpretation  - Information from elifesciences.org

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Investigating the replicability of preclinical cancer biology eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Equally a failure to replicate does not disconfirm a finding An important feature of this system is replication (Hempel 1968  - Information from elifesciences.org

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Figures and data in Adrb2 controls glucose homeostasis by

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

5 AGGGCATTATCCCTGAGGAA −3 Harvard Primer Bank PrimerBank ID 6754426a1 Kcnj11R: 5 TTGCCTTTCTTGGACACGAAG3 Harvard Primer - Information from elifesciences.org

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Functional links between sensory representations choice

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We next wanted to test our hypothesis that choicerelated activity would be associated with further increases in the robustness of 3D  - Information from elifesciences.org

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Intermembrane association of the Sec and BAM translocons

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Precursors of βbarrel OuterMembrane Proteins (OMPs) with cleavable Nterminal signalsequences are targeted to the ubiquitous Secmachinery - Information from elifesciences.org

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The heritability of multimodal connectivity in human brain

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We estimated functional connectivity between 39 fMRIderived cortical ROIs We used the parcellation employed in Colclough et al (Colclough et  - Information from elifesciences.org

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A natural variant of the essential host gene MMS21 restricts

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A novel assay to measure 2micron stability together with a survey of natural variation among Saccharomyces cerevisiae strains reveals novel  - Information from elifesciences.org

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Figures and data in Parvalbuminpositive interneurons eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

images showing colocalization of hM4DimCherry + and PV + cells in PVCre mice infused with AAVDIOhM4DimCherry virus in CA1 or ACC - Information from elifesciences.org

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PPM1H phosphatase counteracts LRRK2 signaling by eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Consistent with Rab proteins comprising diseaserelevant substrates all established pathogenic mutations enhance LRRK2 mediated Rab protein - Information from elifesciences.org

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Lys63linked ubiquitin chain adopts multiple conformational

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

To do so Lys63linked polyubiquitin has to specifically recognize multiple target proteins Structural studies of Lys63linked diubiquitin (K63  - Information from elifesciences.org

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Spontaneous and evoked activity patterns diverge over eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Spontaneous and evoked activity patterns diverge over development Spontaneous neuronal activity in developing neocortical networks: from  - Information from elifesciences.org

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Research Culture: Virtual conferences raise standards for

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Virtual conferences benefit the scientific community by increasing the number the number of online conferences has increased in 2020  - Information from elifesciences.org

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Rapid adaptation to malaria facilitated by admixture in eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Additionally in recent human admixture ancestry contributions from each probability of positive selection at a site of interest - Information from elifesciences.org

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Viral miRNA adaptor differentially recruits miRNAs to target

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

crete seed sequence and the target RNA is sufficient to confer nylation signal (bGH polyA) from PCDNA3 (Invitrogen) were cloned into  - Information from elifesciences.org

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A Dynamic molecular basis for malfunction in disease mutants

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Thus although mutations are localized to different domains and can be distant in space from each other their impact on the structure and  - Information from elifesciences.org

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Figures and data in Research Culture: Virtual conferences

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Virtual conferences benefit the scientific community by increasing Cite this article as: eLife 20209:e62668 doi: 107554/eLife62668 - Information from elifesciences.org

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A thesaurus for a neural population code eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The activity patterns of populations of neurons in the retina are organized as semantic clusters (analogous to synonyms) in which component  - Information from elifesciences.org

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SynGAP isoforms differentially regulate synaptic plasticity and

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

SynGAP is a synaptic Ras GTPaseactivating protein (GAP) with four Cterminal splice variants: α1 α2 β and γ - Information from elifesciences.org

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Molecular function limits divergent protein evolution on eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

As proteins evolve from a common ancestor their sequences and structures diverge from each other (Chothia and Lesk 1986 Povolotskaya and  - Information from elifesciences.org

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Structure of a mitochondrial ATP synthase with bound native

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

ATP synthase is the enzyme that makes ATP molecules It is a multipart complex that straddles the inner membrane of mitochondria  - Information from elifesciences.org

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HIV1 uncoating by release of viral cDNA from capsidlike

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

HIV1 replication commences inside the coneshaped viral capsid but timing CPSF6 displacement occurred rapidly within 30 min of PF74  - Information from elifesciences.org

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HNRNPM controls circRNA biogenesis and splicing fidelity to

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The percentages of green fluorescent protein (GFP) (indicating exon inclusion) and dsRed fluorescent proteins (RFP) (indicting exon  - Information from elifesciences.org

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GPCR signaling inhibits mTORC1 via PKA phosphorylation

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian and Ser/Thr are the phosphorylatable residues (Taylor et al 2008) - Information from elifesciences.org

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Oldest skeleton of a fossil flying squirrel casts new light on the

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

anatomy of flying squirrels is unique being related to the structures that carpalis muscle which runs from the ankle to the tip of the  - Information from elifesciences.org

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Molecular function limits divergent protein evolution on eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Functional conservation is known to constrain protein evolution Nevertheless the longterm divergence patterns of proteins maintaining the  - Information from elifesciences.org

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Research Culture: Virtual conferences raise standards for

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Virtual conference platforms can provide better file sharing data presentation and interactive visualization formats for the speakers and  - Information from elifesciences.org

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The nature of the animacy organization in human ventral

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The animacy organization in human ventral visual cortex is driven by both the presence of animaldiagnostic visual features and the  - Information from elifesciences.org

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Disrupting corticocerebellar communication impairs dexterity

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The flow of neural activity across the corticocerebellar loop enables mice to reach for objects with skill and precision - Information from elifesciences.org

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Structures in multiple conformations reveal distinct transition

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Casey H Zhang Department of Molecular and Cellular Biology Harvard University Cambridge United States  - Information from elifesciences.org

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Ten months of temporal variation in the clinical journey eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Article and author information MSD and unrestricted research grant from MSD and Fisher & Paykel all outside the submitted work - Information from elifesciences.org

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Peer Review: Implementing a "publish then review" model of

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

It means that for all practical purposes eLife is no longer a publisher: rather eLife is now an organization that reviews and certifies  - Information from elifesciences.org

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What do adversarial images tell us about human vision? eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Deep convolutional neural networks (DCNNs) are frequently described as the best current models of human and primate vision - Information from elifesciences.org

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Ribozymecatalysed RNA synthesis using triplet building blocks

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Biochemical techniques were used to engineer a ribozyme that copies RNA strands by adding letters not onebyone but threebythree Using  - Information from elifesciences.org

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The antibiotic bedaquiline activates host macrophage innate

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

tuberculosisinfected macrophages incubated with the drug with an overrepresentation of lysosomeassociated genes BDQ treatment triggered a  - Information from elifesciences.org

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Identification of a stereotypic molecular arrangement of eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We show that endogenous GlyRs exhibit equal receptorscaffold occupancy and constant packing densities of about 2000 GlyRs µm 2 at synapses  - Information from elifesciences.org

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DoubleμPeriscope a tool for multilayer optical recordings

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Imaging across different cortical depths (zaxis) is more The posteromedial thalamic nucleus (POm) sends axons to cortical layers 1 and  - Information from elifesciences.org

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eLife Latest: Our new Ethics Committee

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A new eLife Ethics Committee will advise and develop policy focused on establishing and maintaining the highest standards of research and  - Information from elifesciences.org

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Reversal of the adipostat control of torpor during migration in

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

throughout the annual cycle and suggest a fundamental change in Ethics Animal experimentation: Details of animal husbandry and all  - Information from elifesciences.org

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Mapping brainbehavior space relationships along the eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A datareduced neurobehavioral geometry in psychosis spectrum disorders mapped symptoms stably on to distinct functional brain regions and  - Information from elifesciences.org

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DoubleμPeriscope a tool for multilayer optical recordings

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

To express ChR2 in L5 pyramidal neurons a transgenic mouse line and a Credependent adenoassociated virus vector encoding GCaMP6s - Information from elifesciences.org

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Hostpathogen coevolution increases genetic variation in

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses largely by introducing majoreffect  - Information from elifesciences.org

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MELK is not necessary for the proliferation of basallike breast

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Sirano Dhe Paganon Department of Cancer Biology DanaFarber Cancer Institute Boston United States Contribution - Information from elifesciences.org

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About eLife

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eLife is an initiative from research funders to transform research communication through improvements to science publishing technology and research  - Information from elifesciences.org

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SpikeForest reproducible webfacing groundtruth validation

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

This paper introduces an online web site focused on evaluating different methods of spike sorting: the computational process that extracts  - Information from elifesciences.org

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Low FoxO expression in Drosophila somatosensory neurons

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Amy R Poe†‡ Yineng Xu† Christine Zhang Joyce Lei Kailyn Li innervation of the target field the dendritic or axonal arbor of the  - Information from elifesciences.org

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Figures and data in Neuronspecific knockouts indicate the

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MKRS /TM6B Bloomington Drosophila Stock Center BDSC_3703 Genetic reagent (D melanogaster) VGlutGAL4 BloomingtonDrosophila Stock Center  - Information from elifesciences.org

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Structure of a mitochondrial ATP synthase with bound native

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

ATP synthase is the enzyme that makes ATP molecules It is a multipart complex that straddles the inner membrane of mitochondria the energy  - Information from elifesciences.org

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PDF neuron firing phaseshifts key circadian activity eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A few circadian evening neurons within the Drosophila brain play a key role in driving activity as well as keeping time  - Information from elifesciences.org

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Research Culture: Virtual conferences raise standards for

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Accessibility solutions lessons learned and improvements in policies at one conference and country can be shared with and adopted by other  - Information from elifesciences.org

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Improving a probabilistic cytoarchitectonic atlas of auditory

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

cytoarchitectonic atlas (and in vivo data) to a recent temporal lobe parcellation based on in vivo measurements (Glasser et al 2016) - Information from elifesciences.org

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Changes in global and thalamic brain connectivity in LSD

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5HT) and dopamine receptors Despite the therapeutic and scientific  - Information from elifesciences.org

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Mucosalassociated invariant T (MAIT) cells mediate eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In experimental sepsis MAITdeficient mice had significantly increased mortality and bacterial load and reduced tissuespecific cytokine  - Information from elifesciences.org

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eLife references: Yes we take any format no were not rekeying

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

styles from Harvard to Vancouver reformatting references or finding an EndNote Mendeley ProCite BibTeX or Zotero style to match? - Information from elifesciences.org

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A sleep state in Drosophila larvae required for neural stem cell

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

However it has been difficult to study the effects of sleep in earlier stages of brain development when stem cells divide to create brain  - Information from elifesciences.org

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Dopamine maintains network synchrony via direct modulation

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Dopamine maintains network synchrony via direct modulation of gap junctions in the crustacean cardiac ganglion - Information from elifesciences.org

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Boosts in brain signal variability track liberal shifts in decision

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In no brain region however did we find a changechange relationship between participants liberal–conservative shifts in decision bias and  - Information from elifesciences.org

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eLife references: Yes we take any format no were not rekeying

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Authors can use any reference style when they submit their work to reformatting references or finding an EndNote Mendeley ProCite  - Information from elifesciences.org

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Golgi membrane protein Erd1 Is essential for recycling eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Some of the cytosolic machinery required for the steadystate binds and retrieves ER proteins containing a Cterminal HDEL sequence  - Information from elifesciences.org

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Combining agentbased traitbased and demographic eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A new agentbased model enables predicting how coral species richness and functional diversity affect the functioning and resilience of  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/55993

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Fast and flexible estimation of effective migration surfaces eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

in a steppingstone model of migration and genetic drift (Kimura 1953 Kimura and Weiss 1964) EEMS models the withinsubpopulation  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/61927

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The Natural History of Model Organisms eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The great pond snail is a multipurpose model organism and a contemporary aid the development of novel control measures that reduce  - Information from elifesciences.org

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Chemical and structural investigation of the paroxetinehuman

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

paroxetine binding to the serotonin transporter provides a framework for transporter inhibition and design of smallmolecule inhibitors - Information from elifesciences.org

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Neural signatures of α2Adrenergic agonistinduced eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Moreover dexmedetomidine is unique because a specific α2adrenergic antagonist is used in veterinary medicine to reverse its sedative and  - Information from elifesciences.org

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Equity Diversity and Inclusion: Disabled in Higher Ed eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Equity Diversity and Inclusion: Disabled in Higher Ed Conversations about the lack of diversity in academia need to include the needs and  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/interviews/7b84f248/disabled-in-higher-ed

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Statistical learning attenuates visual activity only for attended

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Crucially this sensory attenuation was only apparent when stimuli were attended and vanished when attention was directed away from the  - Information from elifesciences.org

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Golgi membrane protein Erd1 Is essential for recycling eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We examined the genomewide genetic interactions networks for Δ yeast cells and the suppressing genes were identified by sequencing - Information from elifesciences.org

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Investigating the replicability of preclinical cancer biology eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Abstract Replicability is an important feature of scientific research but aspects of contemporary research culture such as an emphasis on  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/71601

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Magnetic alignment enhances homing efficiency of hunting dogs

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We equipped 27 hunting dogs with GPS collars and action cams let them freely roam in forested areas and analyzed components of homing in over  - Information from elifesciences.org

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Critical role for Piccolo in synaptic vesicle retrieval eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Next we performed FMdye uptake experiments (Smith and Betz 1996) to determine the size of the total recycling pool (TRP) of SVs - Information from elifesciences.org

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Reproducibility in Cancer Biology: Challenges for assessing

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We conducted the Reproducibility Project: Cancer Biology to papers in the field of cancer biology (Errington et al 2014 Table 1) - Information from elifesciences.org

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Pushpull competition between bottomup and topdown

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Some of the hallmarks of selective attention are enhanced neural encoding in sensory cortex of attended features and dynamics (eg envelope of  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/52984.pdf

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Structure of a mitochondrial ATP synthase with bound native

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

ATP synthase is the enzyme that makes ATP molecules It is a multipart complex that straddles the inner membrane of mitochondria the energy  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/51179

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Science Forum: Is preclinical research in cancer biology

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In 2012 reports from two major drug companies – Bayer and Amgen – claimed that fewer than a quarter of animal experiments submitted in support  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/67527

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High social status males experience accelerated epigenetic

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

"Reprogramming to recover youthful epigenetic information and restore vision" Nature 5887836 (2020): 124129) or merely a marker is unclear - Information from elifesciences.org

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Quantifying the relationship between genetic diversity eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

It has long been appreciated that effective population sizes are the estimated diversity in the absence of linked selection ( π 0 ) R - Information from elifesciences.org

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Measurements and models of electric fields in the in vivo

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Direct invivo measurements in the human brain test validity of detailed computational models of trancranial electric stimulation and show  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/18834

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Bacterial flagella grow through an injectiondiffusion mechanism

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The bacterial flagellum is a selfassembling nanomachine The external flagellar filament several times longer than a bacterial cell body  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/23136

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Inherent regulatory asymmetry emanating from network eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/56517

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Mapping singlecell atlases throughout Metazoa eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In addition SAMap uses a graphbased data integration technique to identify reciprocally connected cell types across species with greater  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/66747

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Giant ankyrinB mediates transduction of axon guidance eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

GCs in the primary axon and in collateral branches of cultured cortical neurons from AnkB440 KO mice fail to collapse in response to Sema 3 A - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/69815

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An interactive metaanalysis of MRI biomarkers of myelin eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In terms of specific modalities the survey shows that the most common MRI approach compared with histology was diffusionweighted imaging  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/61523

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Cytotoxic Tcells mediate exerciseinduced reductions in

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Exercise can induce metabolic changes that strikingly impact This is in line with mitochondrial metabolism being ratelimiting in  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/59996

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Golgi localized β1adrenergic receptors stimulate Golgi PI4P

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

PLCβ isoforms stimulated by Gq have been implicated in cardiac hypertrophy driven by cell surface αadrenergic receptors (αAR) (Filtz et al  - Information from elifesciences.org

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Inhibition of mTORC1 by ER stress impairs neonatal βcell

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A systematic analysis of the mechanisms of βcell loss and dysfunction At this stage Akita mice have normal body and pancreatic weight - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/38472

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The Mouse Action Recognition System (MARS) software

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Scoring for social behaviors often takes human annotators 3–4× the MARS pose estimators are trained on a novel corpus of manual pose - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/63720

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Mapping singlecell atlases throughout Metazoa eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

(2019) Fast sensitive and accurate integration of singlecell data with harmony Nature Methods 16:1289–1296 - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/66747

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Two locus inheritance of nonsyndromic midline eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

To identify mutations contributing to common nonsyndromic midline (sagittal and metopic) craniosynostosis we performed exome sequencing of  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/20125

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HIV1 uncoating by release of viral cDNA from capsidlike

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

HIV 1 capsids enter the host cell nucleus where they are partially disrupted to release the viral genome upon completion of reverse  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/64776

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Multiplexed proteomics of autophagydeficient murine eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

of the ATG16L1 protein (Lassen et al 2014 Murthy et al 2014) 15 mg of protein/sample was digested at 25°C for 12 hr with lysyl  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/62320

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Quantifying the relationship between genetic diversity eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

It has long been appreciated that effective population sizes are shorter in large–censussize species increasing the effects of linked  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/67509

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A Drosophila screen identifies NKCC1 as a modifier of NGLY1

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Research Article Dec 14 2020 there have been rapid research advances thanks to the support of two patient organizations (NGLY1org and  - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/57831

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Vision challenges and opportunities for a Plant Cell Atlas eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The PCA efforts include integration of not only singlecell omics data but also spatiotemporal dynamics of single cells and their connection to  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/66877

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Quantitative mapping of human hair greying and reversal in

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

As the hair grows out of the scalp it hardens preserving these if a hair is just above the threshold then it could revert back to  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/67437

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An atlas of polygenic risk score associations to highlight

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Polygenic risk scores (PRS) commonly defined as the sum of traitassociated SNPs weighted by their effect sizes harness findings from GWAS to  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/43657

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Changes in global and thalamic brain connectivity in LSD

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5HT) and dopamine receptors Despite the therapeutic and scientific  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/35082

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Active machine learningdriven experimentation to determine

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Previous computer simulations showed that a machine learning approach termed “active learning” could do a good job of picking a series of  - Information from elifesciences.org

Information accuracy 100%
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Rapid decline of bacterial drugresistance in an antibioticfree

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The resistance mutations identified generally affected the drug targets efflux pumps porins and proteins involved in cell envelope biogenesis - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/47088

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Mechanism for differential recruitment of orbitostriatal eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Chronic alcohol exposure results in a longlasting enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/67065

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A bigdata approach to understanding metabolic rate eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Energy metabolism is measured by powerful and sensitive indirect calorimetry devices Analysis of nearly 10000 wildtype mice from two  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/53560

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Transgenerational inheritance of ethanol preference is caused

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

(2014) Parental olfactory experience influences behavior and neural structure in subsequent generations Nature Neuroscience 17:89–96 - Information from elifesciences.org

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Read more from elifesciences.org information was found here: https://elifesciences.org/articles/45391

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Biologically plausible learning in recurrent neural networks

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Neural activity during cognitive tasks exhibits complex dynamics that flexibly encode taskrelevant variables Chaotic recurrent networks - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/20899

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The population genetics of collateral resistance and sensitivity

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Abstract Resistance mutations against one drug can elicit collateral sensitivity against other drugs Multidrug treatments exploiting such  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/73250

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Science Forum: Ten common statistical mistakes to watch out for

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

This can be achieved without losing statistical power using bootstrapping (2013) Posthoc data analysis: benefits and limitations - Information from elifesciences.org

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Constructing and optimizing 3D atlases from 2D data with

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Allen developmental mouse brain atlas Chon et al 2019 integrated the FranklinPaxinos atlas with the CCFv3 atlas and additional  - Information from elifesciences.org

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Constructing and optimizing 3D atlases from 2D data with

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Applying these methods to the eight developmental stages in the Allen Developing Mouse Brain Atlas (ADMBA) led to more comprehensive and  - Information from elifesciences.org

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06717pdf eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

densed form of chromatin that silences the genes encoded in the DNA and is inherited by binases have been used similarly in the past to - Information from elifesciences.org

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A multifaceted analysis reveals two distinct phases of eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Major thylakoid structural changes occur within 24 hr of deetiolation We determined the dynamics of thylakoid biogenesis during the etioplast–  - Information from elifesciences.org

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Variation of connectivity across exemplar sensory and eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

This may be one explanation for why we find sporadic labeling of thalamic nuclei in our dataset when it is known that the thalamus lacks lateral  - Information from elifesciences.org

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The natverse a versatile toolbox for combining and analysing

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

To analyse neuron data at scale neuroscientists expend substantial clustering neurons by morphology analysing neuroanatomical data  - Information from elifesciences.org

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MetaResearch: Use of the Journal Impact Factor in academic

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Briefly we created a stratified random sample based on the 2015 edition of the Carnegie Classification of Institutions of Higher Education (  - Information from elifesciences.org

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Targeting RASdriven human cancer cells with antibodies to

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

For further characterization each Fab was cloned into an E coli secretion plasmid and expressed typically in yields Juan E Diaz - Information from elifesciences.org

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Alpha1 adrenergic receptor antagonists to prevent eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The clinical picture is similar in Coronavirus disease 2019 (COVID19) caused by SARSCoV2 hyperinflammation compromises organ function in  - Information from elifesciences.org

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Event Report: Aging Geroscience and Longevity Symposium

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

With the population aging older adults are a growing patient demographic the onset and progression of agerelated oral deterioration - Information from elifesciences.org

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Research: Publication bias and the canonization of false facts

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Science is a process of collective knowledge creation in which researchers use experimental theoretical and observational approaches to develop  - Information from elifesciences.org

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TLR induces reorganization of the IgMBCR complex eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Thus TLRmediated signals support participation of B1 cells in immune the frequencies of CD5+ B1 cells transferred to generate the  - Information from elifesciences.org

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Structure of mycobacterial CIII2CIV2 respiratory supercomplex

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203) - Information from elifesciences.org

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Structure of a bacterial ATP synthase eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

This mechanism would allow the Bacillus PS3 ATP synthase to run in reverse establishing a proton motive force by ATP hydrolysis  - Information from elifesciences.org

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Autophagic cell death is dependent on lysosomal membrane

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Cells deficient in the prodeath Bcl2 family members Bax and Bak are known to be resistant to apoptotic cell death and previous we have  - Information from elifesciences.org

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Emergence and propagation of epistasis in metabolic networks

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Mutations that affect a metabolic network generically exhibit epistasis which propagates to higher level phenotypes such as fitness  - Information from elifesciences.org

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Coexpression analysis reveals interpretable gene modules

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In this study we performed comprehensive gene module transeQTL analysis First we used linear regression implemented in MatrixEQTL - Information from elifesciences.org

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Kallikreinkinin blockade in patients with COVID19 to prevent

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The kininkallikrein system is a zymogen system that after activation leads to the release of the nonapetide bradykinin that after binding to  - Information from elifesciences.org

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CEM500K a largescale heterogeneous unlabeled cellular

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

While supervised deep learning (DL) models are effective at the segmentation of objects in natural images (eg of people cars furniture  - Information from elifesciences.org

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Mechanisms of PDZ domain scaffold assembly illuminated by

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Investigations of binding of the scaffold protein PICK1 to transmembrane proteins DNA reagent FLAGβ2 DAT8 LKV + A Madsen et al 2012  - Information from elifesciences.org

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The chloroplast 2cysteine peroxiredoxin functions as eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Thioldependent redox regulation controls central processes in plant 2CysPrxB] peroxiredoxin Q [PrxQ] peroxiredoxin IIE [PrxIIE]) and - Information from elifesciences.org

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Deamidation disrupts native and transient contacts to weaken

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Ubiquitination reactions of TRAF6 either with UBC13 in the presence of OspI or with mutant Q100EUBC13 (dUBC13) show a significant drop in  - Information from elifesciences.org

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Myoglobin primary structure reveals multiple convergent

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The speciose mammalian order Eulipotyphla (moles shrews hedgehogs solenodons) combines Journal of Computational Biology 19:455–477 - Information from elifesciences.org

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Tight nuclear tethering of cGAS is essential for preventing

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

cGAS is an intracellular innate immune sensor that detects doublestranded DNA The presence of billions of base pairs of genomic DNA in all  - Information from elifesciences.org

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Ecological adaptation in Atlantic herring is associated eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

These properties make the Atlantic herring a powerful model to explore how natural selection shapes the genome in a species where genetic drift  - Information from elifesciences.org

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Memory: How the brain constructs dreams eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Deep inside the temporal lobe of the brain the hippocampus has a in using memory to construct novel imagined scenarios and simulate  - Information from elifesciences.org

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Translation of 5′ leaders is pervasive in genes resistant to

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Most of the mRNAs whose translation is resistant to the stressinduced repression of protein synthesis contain upstream open reading frames  - Information from elifesciences.org

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Research Communication: Ways to increase equity diversity

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The eLife EarlyCareer Advisory Group calls for radical changes at eLife and other journals to make science more diverse and inclusive - Information from elifesciences.org

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Adaptation after vastus lateralis denervation in rats eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Cutting the branch of the quadriceps nerve innervating VL abolished the large majority of VL activation during locomotion as illustrated in  - Information from elifesciences.org

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Celltype specific innervation of cortical pyramidal cells at their

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Towards the distal tuft dendrites in upper L1 the relative inhibitory input was at least about 2fold larger for L5 pyramidal cells than for  - Information from elifesciences.org

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Sensitivity of ID NOW and RT–PCR for detection of SARSCoV

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A brief summary of the studies included in our review including the clinical study reported in this paper is described in Table 2 A brief  - Information from elifesciences.org

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Sex differences in biological aging with a focus on human

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Here we present the two main groups of biological aging theories: the senescent theory of aging and the programmed theory of aging - Information from elifesciences.org

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Translocation of interleukin1β into a vesicle intermediate in

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

No competing interests declared Liang Ge Department of Molecular and Cell Biology Howard Hughes Medical Institute University of California  - Information from elifesciences.org

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Chemical and structural investigation of the paroxetinehuman

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Serotonin or 5hydroxytryptamine (5HT) is a chemical messenger which acts We next compared the cryoEM structure of the SERTparoxetine  - Information from elifesciences.org

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Modulation of tonotopic ventral medial geniculate body is

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Recent evidence suggests an involvement of the sensory thalami in speech recognition In particular the auditory thalamus (medial geniculate - Information from elifesciences.org

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Compact and highly active nextgeneration libraries for eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

(2013) Repurposing CRISPR as an RNAguided platform for sequencespecific control of gene expression Cell 152:1173–1183 - Information from elifesciences.org

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MetaResearch: Tracking the popularity and outcomes of all bioRxiv

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The rate of preprint uploads to bioRxiv continues to grow Journal impact factor and access status of the 30 journals that have published  - Information from elifesciences.org

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Protective effect of Mediterraneantype glucose6phosphate

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Claims have been made that there is no malaria protective effect provided (2018) Favism and Glucose6Phosphate dehydrogenase deficiency - Information from elifesciences.org

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Vascular Biology: Severing umbilical ties eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The umbilical vein on the other hand remains open for longer Rapid umbilical artery closure prevents blood loss in the newborn as it detaches  - Information from elifesciences.org

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The endoplasmic reticulum not the pH gradient drives eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In various cell types when the lysosomal pH gradient is dissipated lysosomal storage disease cell lines by altering calcium homeostasis - Information from elifesciences.org

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Par3 interacts with Prickle3 to generate apical PCP complexes

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Par3 is polarized in the plane of the vertebrate neural plate binds and of Par3 in neural plate PCP we examined whether Par3 forms a - Information from elifesciences.org

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Integrated systems analysis reveals conserved gene networks

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Spinal cord injury (SCI) is a devastating neurological condition for which (2001) The Sygen multicenter acute spinal cord injury study - Information from elifesciences.org

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The interplay of RNA:DNA hybrid structure and G eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Replication products are digested with ClaI prior to gel analysis to each sample was digested with ClaI (Neb) in 1 × CutSmart buffer and - Information from elifesciences.org

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Decreasing human body temperature in the United States

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Analysis using body mass index (BMI) and BMI adjusted for height Although there are many factors that influence resting metabolic rate  - Information from elifesciences.org

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Evolution of pathogen tolerance and emerging infections eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Meanwhile they can also spread the infection efficiently by (2001) Imperfect vaccines and the evolution of pathogen virulence - Information from elifesciences.org

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Assembly status transition offers an avenue for activity eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We next sought to compare the glutamine synthesis activity of these stable decamer and then evaluate the impact on catalytic activity - Information from elifesciences.org

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Quantifying the relationship between genetic diversity eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

It has long been appreciated that effective population sizes are between diversity and census size with the predicted relationship under  - Information from elifesciences.org

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28 Å resolution reconstruction of the Thermoplasma eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Highenergy electrons are then transmitted through the protein sample (2015) Atomicaccuracy models from 45A cryoelectron microscopy  - Information from elifesciences.org

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Cerebral blood flow and cerebrovascular reactivity are eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We assessed cerebrovascular function longitudinally in TgSwDI mice with arterial spin labeling (ASL)magnetic resonance imaging (MRI) and laser  - Information from elifesciences.org

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Pregnancyassociated plasma proteinaa supports hair cell

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Hair cell survival and mitochondrial function is supported by an extracellular stimulator of IGF1 signaling the protease  - Information from elifesciences.org

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Linking mPFC circuit maturation to the developmental eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Reducing the levels of brainderived neurotrophic factor decreases PV protein expression The Journal of Neuroscience 37:2976–2985 - Information from elifesciences.org

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Genetic Screening: Making better CRISPR libraries eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

(2015) Genomescale transcriptional activation by an engineered (2014) Genomescale CRISPRCas9 knockout screening in human cells - Information from elifesciences.org

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ERluminal [Ca2+] regulation of InsP3 receptor gating eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Calcium release from the endoplasmic reticulum through the IP3 The smooth and rough ER fractions below the interface between 138 M and  - Information from elifesciences.org

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In vivo identification of GTPase interactors by mitochondrial

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

MitoID can also efficiently identify effectors and GAPs of Rho and Ras of the Rheb GAP (Manning and Cantley 2003) and the VATPase  - Information from elifesciences.org

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Julieta E Lischinsky eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Livio Oboti Center for Neuroscience Research Childrens National Medical Center Washington DC United States  - Information from elifesciences.org

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The structure of the endogenous ESX3 secretion system eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The ESX (or Type VII) secretion systems are protein export systems in negative stain electron microscopy structure of ESX5 shows a  - Information from elifesciences.org

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A large effective population size for established withinhost

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Once an influenza infection is established selection acts efficiently in favouring fitter viral genotypes its effects being limited only  - Information from elifesciences.org

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Modelling primaquineinduced haemolysis in G6PD deficiency

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Radical cure of vivax malaria in G6PD deficient patients of oxidant haemolysis caused by primaquine and provided an alternative once  - Information from elifesciences.org

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A large effective population size for established withinhost

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Based on the analysis of sequence polymorphism authors infer a relatively large effective population size ~10 7 during chronic infection in  - Information from elifesciences.org

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How to measure and evaluate binding affinities eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

So determining a binding equilibrium constant requires showing that the protein concentration that gives halfsaturation to determine - Information from elifesciences.org

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Datadriven identification of potential Zika virus vectors eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

For example the Zika virus was discovered in 1947 Group factor Japanese Encephalitis Ntaya Yellow Fever Aroa Dengue Kokobera  - Information from elifesciences.org

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Nucleosomes influence multiple steps during replication

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Specific CREs rescued replication of these templates if added prior to DNA helicases around the origin DNA (Bell and Labib 2016) - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/22512

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KRABzinc finger protein gene expansion in response to

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Unbiased ChIPseq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRABZFP) clusters reveal that  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/56337

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A century of trends in adult human height eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The NCD Risk Factor Collaboration set out to find out how tall The early African advantage over Asia may also have been partly due to  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/13410

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Statistical context dictates the relationship between feedback

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The P300 an electroencephalography (EEG) component known to be evoked by surprising events predicts learning in a bidirectional manner  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/46975

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MutSα maintains the mismatch repair capability by inhibiting

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Eukaryotic mismatch repair (MMR) utilizes singlestrand breaks as NPE promotes gapdirected MMR with efficient DNA synthesis at the gap  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/15155

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Mucosalassociated invariant T (MAIT) cells mediate eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Mucosalassociated invariant T (MAIT) cells are innatelike T cells enriched in mucosal tissues that recognize bacterial ligands - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/55615

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Local online learning in recurrent networks with random

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

A biologically plausible learning rule enables recurrent neural networks to The nonlinear activation function of the RNN units was ϕ  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/43299

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Vocal and locomotor coordination develops in association

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

(3) How do realtime fluctuations in arousal relate to vocal production noisier calls when locomotor activity was high and longer  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/41853

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Tight nuclear tethering of cGAS is essential for preventing

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The discovery of cGAS and cGAMP and subsequent structural studies of cGAS as the basis for self/nonself discrimination by cGAS - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/47491

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The E3 ubiquitin ligase IDOL regulates synaptic ApoER2

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein https://doiorg/101016/jneuron200507007 - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/29178

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Shapeinvariant encoding of dynamic primate facial eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

For example monkey facial movements include speciesspecific features such as ear motion that are not present in human expressions Do the  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/61197

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Equity Diversity and Inclusion: Disabled in Higher Ed eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Conversations about the lack of diversity in academia need to include the needs and experiences of students and staff with disabilities - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/interviews/7b84f248/disabled-in-higher-ed

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CRISPRi is not strandspecific at all loci and redefines the

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

CRISPR interference (CRISPRi) which uses small guide RNAs to target by which antisense transcription functions in gene regulation is  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/29878

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New footprints from Laetoli (Tanzania) provide evidence for

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The tall individual may have been the dominant male of a larger group § Estimation based on the relationship between foot length and  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/19568

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Tight nuclear tethering of cGAS is essential for preventing

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The cGASSTING DNA sensing pathway has emerged as a key innate immune response that is important for antiviral immunity (Goubau et al 2013)  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/47491

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The role of scaffold reshaping and disassembly in dynamin

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We change the scaffold geometry by tuning the equilibrium distances between its CG beads Molecular Biology of the Cell 25:3595–3609 - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/39441

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Alpha1 adrenergic receptor antagonists to prevent eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We previously demonstrated that alpha1 adrenergic receptor (⍺1AR) antagonists can prevent hyperinflammation and death in mice Here we  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/61700

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Acyl chain asymmetry and polyunsaturation of brain eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The abilities to vesiculate and to act as selective barriers are two fundamental properties of cellular membranes Without membrane vesiculation - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/34394

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MetaResearch: Journal policies and editors opinions on peer

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Peer review comes in many forms with each journal adopting their own unique avenue for authors to influence who reviews their article - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/62529

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Selection for increased tibia length in mice alters skull eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Artificial selection for increased tibia length in mice made their skulls longer narrower and flatter suggesting that even distant  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/67612

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Vesicles: Looking inside the cell eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Advances in imaging techniques have shed new light on the structure of vesicles formed by COPI protein complexes - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/33650

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CryoEM structures of the caspaseactivated protein XKR9

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Chemical compound drug 1palmitoyl2oleoylsnglycero3phospho(1racglycerol) (18:1 06:0 POPG) Avanti Polar Lipids 840457C - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/69800/figures

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A flexible framework for simulating and fitting generalized drift

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The driftdiffusion model (DDM) is an important decisionmaking model GDDM framework to other software packages for diffusion modeling - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/56938

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A large effective population size for established withinhost

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

To resolve this issue we evaluated the relative importance of selection and genetic drift during a case of influenza infection The balance  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/56915

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Understanding patterns of HIV multidrug resistance eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

In tripledrugtreated HIV partially resistant viruses can spread and Despite tripledrug therapies becoming available in highincome  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/69032

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Structure of a bacterial ATP synthase eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Adenosine triphosphate (ATP) synthases are multisubunit protein complexes that use an electrochemical proton motive force across a membrane to  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/43128

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A large effective population size for established withinhost

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

We here estimate a mean effective population size for an established withinhost while high were smaller than for our flu B case  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/56915

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Network structure of brain atrophy in de novo Parkinsons

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The PDICA network includes all components of the basal ganglia (substantia nigra subthalamic nucleus nucleus accumbens putamen caudate - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/08440

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The scaffold protein Nde1 safeguards the brain genome

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The protein encoded by the NDE1 gene acts as a scaffold for many During the S phase of metazoan cells various chromosomal domains are  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/03297

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Interneuronspecific gamma synchronization indexes cue

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Interneuronspecific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/69111

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A machinevision approach for automated pain measurement

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

Our statistical software platform PAWS (Pain Assessment at Withdrawal However the traditional approach of manually scoring paw lifting  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/57258

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Kallikreinkinin blockade in patients with COVID19 to eLife

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Author: openj-gate.com ~ Tags: elifesciences.org ~ Date: 2022/11/19

The kininkallikrein system is a zymogen system that after activation leads to the release of the nonapetide bradykinin that after binding  - Information from elifesciences.org

Information accuracy 100%
Read more from elifesciences.org information was found here: https://elifesciences.org/articles/57555

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