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Amide Bond Bioisosteres: Strategies Synthesis and Successes

pubs.acs.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

To date several amide bioisostere classes are known including 123triazole oxadiazole imidazole tetrazole pyrazole indole pyridine  - Information from pubs.acs.org

Information accuracy 100%
Amide bioisosteres information was found here: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00530

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Amide Bond Bioisosteres: Strategies Synthesis PubMed

pubmed.ncbi.nlm.nih.gov

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The amide functional group plays a key role in the composition of biomolecules including many clinically approved drugs - Information from pubmed.ncbi.nlm.nih.gov

Information accuracy 100%
Amide bioisosteres information was found here: https://pubmed.ncbi.nlm.nih.gov/32686940/

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Ester Bioisosteres Cambridge MedChem Consulting

www.cambridgemedchemconsulting.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Ester and Amide Bioisosteres Storeoperated calcium entry (SOCE) is a pivotal mechanism in calcium homeostasis bioisosteric replacement of a  - Information from www.cambridgemedchemconsulting.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.cambridgemedchemconsulting.com/resources/bioisoteres/ester_bioisosteres.html

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Application of Amide Bioisosteres in the Optimization of Lead

manu56.magtech.com.cn

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteres play a role in the same related biochemical system as agonist or antagonist which possessed in related biological activities The amide structure  - Information from manu56.magtech.com.cn

Information accuracy 100%
Amide bioisosteres information was found here: http://manu56.magtech.com.cn/progchem/EN/10.7536/PC160414

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Bioisosteres v2 Recent Trends and Tactics Baran Lab

baranlab.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

2018 61 5822 Amide bioisosteres: J Med Chem ASAP General overview: Brown N Bioisosteres in Medicinal Chemistry Wiley‐VCH 2012 - Information from baranlab.org

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Amide bioisosteres information was found here: https://baranlab.org/wp-content/uploads/2020/11/Bioisosteres-v2-Recent-Trends-and-Tactics.pdf

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Amide Bond Bioisosteres: Strategies Synthesis and Successes

experts.nebraska.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Herein we review the strategic decisions in selecting an amide bioisostere (the why) synthetic routes to each (the how) and success stories  - Information from experts.nebraska.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://experts.nebraska.edu/en/publications/amide-bond-bioisosteres-strategies-synthesis-and-successes

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Isosteres in Medicinal Chemistry

www.scripps.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Friedman (1951): Bioisosteres are atoms or molecules that fit Replacement of the sensitive amide bond by various groups - Information from www.scripps.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://www.scripps.edu/baran/images/grpmtgpdf/Mitsos_Feb_06.pdf

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An example of bioisosteres Aminopyrine

labs.chem.ucsb.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The trifluoroethylamine can act as an isostere of an amide moiety in peptidebased molecules Trifluoroethylamines as amide isosteres Functional mimicry is  - Information from labs.chem.ucsb.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://labs.chem.ucsb.edu/zakarian/armen/10---bioisostere-ucsb-5.potx

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Amide Bond Bioisosteres: Strategies Synthesis and Successes

www.researchgate.net

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The amide bond is one of the most important and fascinating functional groups in organic chemistry and biochemistry owing to its widespread occurrence in  - Information from www.researchgate.net

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Amide bioisosteres information was found here: https://www.researchgate.net/publication/343091917_Amide_Bond_Bioisosteres_Strategies_Synthesis_and_Successes

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Evaluation of amide bioisosteres leading to 123triazole

www.rti.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Evaluation of amide bioisosteres leading to 123triazole containing compounds as GPR88 agonists: Design synthesis and structureactivity relationship  - Information from www.rti.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.rti.org/publication/evaluation-amide-bioisosteres-leading-123-triazole-containing-compounds-gpr88-agonists

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123Triazoles as Amide Bioisosteres: Discovery of a New Class of

scholarship.miami.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

123Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV1 Vif Antagonists Idrees Mohammed Indrasena Reddy Kummetha  - Information from scholarship.miami.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://scholarship.miami.edu/esploro/outputs/journalArticle/123-Triazoles-as-Amide-Bioisosteres-Discovery-of/991031578297802976

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Amide Bond Bioisosteres: Strategies Synthesis and Successes

europepmc.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Amide Bond Bioisosteres: Strategies Synthesis and Successes Herein we review the strategic decisions in selecting an amide bioisostere (the why)  - Information from europepmc.org

Information accuracy 100%
Amide bioisosteres information was found here: https://europepmc.org/article/med/32686940

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Evaluation of 123‐Triazoles as Amide Bioisosteres In Cystic

chemistry-europe.onlinelibrary.wiley.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Abstract The 123triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts - Information from chemistry-europe.onlinelibrary.wiley.com

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Amide bioisosteres information was found here: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201805919

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Reductive Functionalization of Amides in Synthesis and for

www.frontiersin.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Reductive functionalization of amides in context of latestage functionalization and bioisosteres (A) Comparison of triflic  - Information from www.frontiersin.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.frontiersin.org/articles/655849

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Bioisostere Wikipedia

en.wikipedia.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

In medicinal chemistry bioisosteres are chemical substituents or groups with similar Procainamide an amide has a longer duration of action than Procaine  - Information from en.wikipedia.org

Information accuracy 100%
Amide bioisosteres information was found here: https://en.wikipedia.org/wiki/Bioisostere

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Application of Bioisosteres in Drug Design

www.f.u-tokyo.ac.jp

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

~Amide and Ester Isosteres ~Phenyl Ring Isosteres 3 Oxetanes in Drug Discovery ~Physicochemical Properties of Oxetanes - Information from www.f.u-tokyo.ac.jp

Information accuracy 100%
Amide bioisosteres information was found here: https://www.f.u-tokyo.ac.jp/~kanai/seminar/pdf/Lit_Y_Morita_M1.pdf

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14Disubstituted 123Triazoles as Amide Bond Surrogates

www.mdpi.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

This study shows that the 123triazole is not in all cases a universal bioisostere for a transamide bond as their incorporation into the peptide can  - Information from www.mdpi.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.mdpi.com/1420-3049/25/16/3576/htm

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SwissBioisostere 2021: updated structural Oxford Academic

academic.oup.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

At several stages of drug discovery bioisosteric replacement is a common (26) can arguably be considered as true amide bioisosteres - Information from academic.oup.com

Information accuracy 100%
Amide bioisosteres information was found here: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab1047/6426059

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Trisubstituted acylhydrazines as tertiary amide bioisosteres: HCV

www.infona.pl

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The use of a trisubstituted acylhydrazine as an isostere of a tertiary amide was explored in a series of HCV NS5B thumb site II inhibitors - Information from www.infona.pl

Information accuracy 100%
Amide bioisosteres information was found here: https://www.infona.pl/resource/bwmeta1.element.elsevier-4ae2566f-afdd-3894-ba3d-a0f5fa8dd36e

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Identification of amide bioisosteres of triazole oxytocin

www.semanticscholar.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists although SAR for potency and  - Information from www.semanticscholar.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.semanticscholar.org/paper/Identification-of-amide-bioisosteres-of-triazole-Brown-Ellis/b4e27e118755b4cb97c85a87bedd2e527d23959b

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Stable pantothenamide bioisosteres the journal of antibiotics

www.nature.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Stable pantothenamide bioisosteres: novel antibiotics for Grampositive bacteria Patrick A M Jansen Danique A van der Krieken  - Information from www.nature.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.nature.com/articles/s41429-019-0196-6

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Bioisosterism: A Rational Approach in Drug Design

mch.estranky.sk

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Amide Group Bioisosteres successful use of bioisosteres have been included the isosterism is that bioisosteres affect the same phar - Information from mch.estranky.sk

Information accuracy 100%
Amide bioisosteres information was found here: https://mch.estranky.sk/file/228/1996chemrev96-3147-76_bioisosterism.pdf

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Applications of fluorine to the construction of bioisosteric

www.tandfonline.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

In addition the classic exploitation of trifluoroethylamine group as an amide bioisostere is discussed In each of the case studies presented  - Information from www.tandfonline.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.tandfonline.com/doi/abs/10.1080/17460441.2021.1933427

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Allenamide as a bioisostere of acrylamide in the design and

pubs.rsc.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Our study indicates that the allenamide group could serve as an alternative electrophilic warhead in the design of targeted covalent inhibitors and this  - Information from pubs.rsc.org

Information accuracy 100%
Amide bioisosteres information was found here: https://pubs.rsc.org/en/content/articlelanding/2018/md/c7md00571g

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123triazoles as amide bioisosteres: Discovery of a new class of

miami.pure.elsevier.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

123triazoles as amide bioisosteres: Discovery of a new class of potent HIV1 Vif antagonists Idrees Mohammed Indrasena Reddy Kummetha  - Information from miami.pure.elsevier.com

Information accuracy 100%
Amide bioisosteres information was found here: https://miami.pure.elsevier.com/en/publications/123-triazoles-as-amide-bioisosteres-discovery-of-a-new-class-of-p

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The Influence of Bioisosteres in Drug Design SpringerLink

link.springer.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The application of bioisosteres in drug discovery is a establish an interaction with the C atom of the backbone amide CO of Asn98 at a  - Information from link.springer.com

Information accuracy 100%
Amide bioisosteres information was found here: https://link.springer.com/chapter/10.1007/7355_2013_29

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Amide bioisosteres Publications PubFacts

www.pubfacts.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

College of Pharmacy Yeungnam University Gyeongsan 38541 Korea Two novel bioisosteres of cabozantinib and were designed and synthesized The benzene ring  - Information from www.pubfacts.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.pubfacts.com/search/Amide+bioisosteres

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Drug design principles Stereoelectronics

www.stereoelectronics.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The role of the common functional groups Isosteres and bioisosteres and secondary amines could be used to check whether the amide is acting as an HBD  - Information from www.stereoelectronics.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.stereoelectronics.org/webDD/DD_04.html

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3MF5: Hepatitis C virus polymerase NS5B (BK) with amide

www.rcsb.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Conformational modeling has been successfully applied to the design of cyclic bioisosteres used to replace a conformationally rigid amide - Information from www.rcsb.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.rcsb.org/structure/3MF5

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Trisubstituted acylhydrazines as tertiary amide bioisosteres

agris.fao.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Trisubstituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors [2012] Canales Eda Carlson Joseph S Appleby Todd  - Information from agris.fao.org

Information accuracy 100%
Amide bioisosteres information was found here: https://agris.fao.org/agris-search/search.do?recordID=US201500130803

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PRIME PubMed Identification of amide bioisosteres of triazole

www.unboundmedicine.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists A range of potent analogues were  - Information from www.unboundmedicine.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.unboundmedicine.com/medline/citation/20189387/Identification_of_amide_bioisosteres_of_triazole_oxytocin_antagonists_

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Chemical Biology and Drug Development Rana Lab

ranalab.ucsd.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

(2016) 123Triazoles as amide bioisosteres: Discovery of a new class of potent HIV1 Vif antagonists Journal of Medicinal Chemistry 59 76777682 - Information from ranalab.ucsd.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://ranalab.ucsd.edu/sample-page/chemical-biology-and-drug-development/

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Surveying heterocycles as amide bioisosteres within a series

www.meta.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278 Bioorganic & Medicinal Chemistry Letters - Information from www.meta.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.meta.org/papers/surveying-heterocycles-as-amide-bioisosteres/30910459

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Design and Synthesis of Bioisosteres of Acylhydrazones as

research.rug.nl

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The most successful bioisostere is equipotent bears an amide linker and we confirmed its binding mode by Xray crystallography Having some validated  - Information from research.rug.nl

Information accuracy 100%
Amide bioisosteres information was found here: https://research.rug.nl/files/76824714/Jumde_et_al_2018_ChemMedChem.pdf

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Jake Doiron School of Graduate Studies LSU Health New

graduatestudies.lsuhsc.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Structural Consequences of the 123Triazole as an Amide Bioisostere in Evaluation of 123triazoles as amide bioisosteres in cystic fibrosis  - Information from graduatestudies.lsuhsc.edu

Information accuracy 100%
Amide bioisosteres information was found here: https://graduatestudies.lsuhsc.edu/md_phd/jake_doiron.aspx

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Amide Bond Bioisosteres: Strategies Synthesis and Successes

www.x-mol.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The amide functional group plays a key role in the composition of biomolecules including many clinically approved drugs - Information from www.x-mol.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.x-mol.com/paper/1285278876615491584

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Optimizing Drug Properties LeadtoDrug Design UZH

www.chem.uzh.ch

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Blocks hydrolysis of terminal amide Metabolic Drug Stability Replace labile ester with more stable urethane or amide bioisostere for amide - Information from www.chem.uzh.ch

Information accuracy 100%
Amide bioisosteres information was found here: http://www.chem.uzh.ch/zerbe/MedChem/MedChem5_Lead.pdf

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15Disubstituted 123Triazoles as Amide Bond Isosteres

hal.archives-ouvertes.fr

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

bioisosteres of amide bonds in peptidomimetics to modify the pharmacological properties of peptides or proteins1620 The systematic  - Information from hal.archives-ouvertes.fr

Information accuracy 100%
Amide bioisosteres information was found here: https://hal.archives-ouvertes.fr/hal-03178434/document

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Preparation of novel anthranilic acids as antibacterial agents

www.sigmaaldrich.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Extensive evaluation of alternative amide bioisosteres connecting the A and the Brings by Atli Thorarensen Brian D Wakefield Donna L Romero  - Information from www.sigmaaldrich.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.sigmaaldrich.com/FR/fr/tech-docs/paper/84632

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Bioisosterism: A Useful Strategy for Molecular Modification

www.lassbio.icb.ufrj.br

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Other common examples of amide function bioisosteres include the “retroamide” groups ie: ACONHB ⇒ A NHCOB and alkylydene (CHCH2) [472] Wrobel and  - Information from www.lassbio.icb.ufrj.br

Information accuracy 100%
Amide bioisosteres information was found here: http://www.lassbio.icb.ufrj.br/download/cursos_semin/2015/bioisosterism2015.pdf

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The Use of Bioisosterism in Drug Design and Molecular

citeseerx.ist.psu.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteres are atoms or group of molecules that fit the broadest definition for isosteres They Amide group bioisosteres 22 B4 - Information from citeseerx.ist.psu.edu

Information accuracy 100%
Amide bioisosteres information was found here: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.301.520&rep=rep1&type=pdf

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PBDA 1 Lecture 15 Bioisosterism analogs Flashcards Quizlet

quizlet.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Isosteric replacemet or Bioisosteric replacement Replacement or modification of specific Image: Nonclassical bioisosteres for Amide group - Information from quizlet.com

Information accuracy 100%
Amide bioisosteres information was found here: https://quizlet.com/431936539/pbda-1-lecture-15-bioisosterism-analogs-flash-cards/

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Amide Bond Bioisosteres: Strategies Synthesis 文献云下载

download.xuebalib.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

bioisosteres in drug design2731 along with a more recent review focused on amide bioisosteres32 This perspective aims to be a reference  - Information from download.xuebalib.com

Information accuracy 100%
Amide bioisosteres information was found here: http://download.xuebalib.com/ba3rRqG0nbWr.pdf

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Bioisosteric Replacement as a Tool in AntiHIV Drug Design

mdpi-res.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Figure 7 Diaminosquarate bioisostere for the guanidine moiety as a novel HIV1 TatTAR RNA inhibitor Amide and Ester Bioisosterism - Information from mdpi-res.com

Information accuracy 100%
Amide bioisosteres information was found here: https://mdpi-res.com/d_attachment/pharmaceuticals/pharmaceuticals-13-00036/article_deploy/pharmaceuticals-13-00036-v2.pdf

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Pyrazoles as nonclassical bioisosteres in DOCKSCICOM

docksci.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The results indicate that pyrazoles are suitable bioisosteric replacements of amide functional groups The study is an example of managing bioisosteric - Information from docksci.com

Information accuracy 100%
Amide bioisosteres information was found here: https://docksci.com/pyrazoles-as-non-classical-bioisosteres-in-prolylcarboxypeptidase-prcp-inhibitor_5af52d96d64ab26364f70562.html

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bioisosterismopdf UFPR

www.quimica.ufpr.br

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteres are atoms or group of molecules that fit the broadest definition for isosteres They Amide group bioisosteres 22 B4 - Information from www.quimica.ufpr.br

Information accuracy 100%
Amide bioisosteres information was found here: http://www.quimica.ufpr.br/nunesgg/QIM__PG/material%20para%20estudo/bioisosterismo.pdf

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12Difunctionalized Bicyclo[111]pentanes ChemRxiv

chemrxiv.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteres for ortho/metaSubstituted Arenes and 21 underwent amide bond coupling to obtain Meclizine bioisosteres 18 and 19 in 45% and - Information from chemrxiv.org

Information accuracy 100%
Amide bioisosteres information was found here: https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c7511fbb8c1a389e3dbc11/original/1-2-difunctionalized-bicyclo-1-1-1-pentanes-long-sought-after-bioisosteres-for-ortho-meta-substituted-arenes.pdf

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Stephen Aller (0000000303795534) ORCID

orcid.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Structural Consequences of the 123‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770 - Information from orcid.org

Information accuracy 100%
Amide bioisosteres information was found here: https://orcid.org/0000-0003-0379-5534

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Design and Synthesis of Phosphonoacetic Acid (PPA) Ester

journals.sagepub.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide in order to verify the possible interaction of the proposed bioisosteric moieties - Information from journals.sagepub.com

Information accuracy 100%
Amide bioisosteres information was found here: https://journals.sagepub.com/doi/abs/10.1177/095632020301400403

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ChemMedChem on Twitter: "K Auclair McGillU K Saliba

twitter.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

et al report triazole rings as amide #bioisosteres Such #antimalarial pantothenamide analogues resist degradation by pantetheinases  - Information from twitter.com

Information accuracy 100%
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Mark Turlington Berry College

www.berry.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Evaluation of 123Triazoles as Amide Bioisosteres in Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX770 and VX809 Chem Eur J 2019 - Information from www.berry.edu

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Amide bioisosteres information was found here: https://www.berry.edu/academics/fs/_assets/mturlington-cv.pdf

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Oxetanes SpiroChem TailorMade Molecules

spirochem.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Oxetanylamines can be seen and used as bioisosteres of amide fragments Why oxetanes? The use of oxetanes in drug discovery has known an  - Information from spirochem.com

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Amide bioisosteres information was found here: https://spirochem.com/catalog/oxetanes.html

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In vitro evaluation of Nmethyl amide tripeptidomimetics as

pharmacy.ku.dk

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

The aim of the present study was to evaluate the general application of Nmethyl amide bioisosteres as peptide bond replacements in tripeptides in order to  - Information from pharmacy.ku.dk

Information accuracy 100%
Amide bioisosteres information was found here: https://pharmacy.ku.dk/research/cns-drug-delivery-barrier-modelling/?pure=en%2Fpublications%2Fin-vitro-evaluation-of-nmethyl-amide-tripeptidomimetics-as-substrates-for-the-human-intestinal-ditripeptide-transporter-hpept1(f644a89d-f856-4808-9db0-1cbb633a717a).html

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Publications Dr James A Bull Imperial College London

www.imperial.ac.uk

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

title {Aminooxetanes as amide isosteres by an alternative AB Bioisosteres provide valuable design elements for medicinal chemists to adjust the  - Information from www.imperial.ac.uk

Information accuracy 100%
Amide bioisosteres information was found here: https://www.imperial.ac.uk/people/j.bull/publications.html?respub-action=citation.html&id=1234377&noscript=noscript

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The powerful symbiosis between synthetic and medicinal

www.future-science.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteres have similar shape and connectivity to the Although conformational studies of an Ntrifluoromethyl amide showed a lower  - Information from www.future-science.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.future-science.com/doi/pdf/10.4155/fmc-2021-0062

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PDB 4eo8 citation summary ‹ Protein Data Bank in Europe

www.ebi.ac.uk

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

4eo8: Trisubstituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors - Information from www.ebi.ac.uk

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Amide bioisosteres information was found here: https://www.ebi.ac.uk/pdbe/entry/pdb/4eo8/citations

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Article Structureactivity relationships of antiplasmodial

escholarship.mcgill.ca

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

We previously reported that replacement of the labile amide bond with a triazole ring not amide bioisosteres · Plasmodium falciparum  - Information from escholarship.mcgill.ca

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Amide bioisosteres information was found here: https://escholarship.mcgill.ca/concern/articles/dv13zz06x

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LEMOINE SAMUEL J MS The Development and Uncg

libres.uncg.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Bioisosteric Software Program for the Development of New Pharmaceuticals (2014) Parent compound with amidebased bioisosteres and - Information from libres.uncg.edu

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Amide bioisosteres information was found here: https://libres.uncg.edu/ir/uncg/f/Lemoine_uncg_0154M_11438.pdf

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Search results Scholarly Publications

scholarlypublications.universiteitleiden.nl

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Enabled Filters () Amide bioisosteres Sort Options Date (year) · Author / Creator · Title Refine Results Availability Open access (1) + Faculty - Information from scholarlypublications.universiteitleiden.nl

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Application of Amide Bioisosteres in the JGlobal

jglobal.jst.go.jp

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Article “Application of Amide Bioisosteres in the Optimization of Lead Compounds” Detailed information of the JGLOBAL is a service based on  - Information from jglobal.jst.go.jp

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Amide bioisosteres information was found here: http://jglobal.jst.go.jp/en/public/20090422/201702270917809656

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Surveying heterocycles as amide bioisosteres within a series of

www.researcher-app.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

as bioisosteric replacements for a metabolically labile amide moiety within a 134oxadizaole ring system as an effective bioisostere for the amide - Information from www.researcher-app.com

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Amide bioisosteres information was found here: https://www.researcher-app.com/paper/2476633

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Amidinohydrazones as Guanidine Bioisosteres BetaSheetorg

beta-sheet.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Abstract╨We describe a new class of potent nonamidebased small molecule thrombin inhibitors in which an amidinohydrazone - Information from beta-sheet.org

Information accuracy 100%
Amide bioisosteres information was found here: http://beta-sheet.org/resources/86-Aminohydrazones-as-Guanidine.pdf

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Advances in Triazole Chemistry Page 46 Google Books Result

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

4Hydroxy123triazole moiety as bioisostere of the carboxylic acid function: a Evaluation of 123‐triazoles as amide bioisosteres in cystic fibrosis  - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=LsULEAAAQBAJ&pg=PA46&lpg=PA46&dq=amide+bioisosteres&source=bl&ots=yIkiftzmrA&sig=ACfU3U21c6fXlrrhM8ASvGJlkWS6LhOGjg&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQj6ARAD

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Bioisosteres Hiroyuki Kobayashi Jan SlidePlayer

slideplayer.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

An example of bioisosteres Aminopyrine Marketed as an analgesic and Amide isosteres have typically been of interest as a means of modulating polarity  - Information from slideplayer.com

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Amide bioisosteres information was found here: https://slideplayer.com/slide/10412082/

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The Dopamine Receptors Page 108 Google Books Result

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

59 Binding affinities of several amides with butylene linkers Ki values in nM As described for DPATs heterocyclic bioisosteres are also known for the  - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=9DBnY_R-Mt0C&pg=PA108&lpg=PA108&dq=amide+bioisosteres&source=bl&ots=4BPGuso63M&sig=ACfU3U3eQZtPSL7RMH0Cki1bSXS9IoMNbQ&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQjyARAD

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Current Medicinal Chemistry Page 384 Google Books Result

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

COR Scheme XllI: Synthesis of 2monosubstituted amide bioisosteres of pseudoglycerides Reagents and conditions: a) RiCOCl diethylether: or a)  - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=MBQz9v-4ZGEC&pg=PA384&lpg=PA384&dq=amide+bioisosteres&source=bl&ots=r-H0zzzfwu&sig=ACfU3U3vWzd9jWAOb-PNPhWNIryAVRj44Q&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQj5ARAD

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Issues in Medical Chemistry: 2013 Edition

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

(2012 Jul 18) Gilead Sciences Inc Foster City: Trisubstituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors By a News  - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=aiao1EtyvJYC&pg=PA976&lpg=PA976&dq=amide+bioisosteres&source=bl&ots=XQz_6tlmtU&sig=ACfU3U1Qfz_ZEgKiBauFaVAUVaZaTsZdmg&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQj7ARAD

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DiversityOriented Synthesis: Basics and Applications in

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

A triazole ring and a ketopiperazine moiety were introduced as bioisosteres of the amide to improve the instability of the peptides [55] - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=2EFF3XRfJTcC&pg=SA3-PA30&lpg=SA3-PA30&dq=amide+bioisosteres&source=bl&ots=vWCYlb6Wsy&sig=ACfU3U3lrkgtqTug3Zpn2mIlD92WmyFYZg&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQjtARAD

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New Developments in Medicinal Chemistry

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Subsequently the authors synthesized amide bioisosteres of the previously antagonists and the higher synthetic accessibility of the amides (Fig - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=_uZrDgAAQBAJ&pg=PA228&lpg=PA228&dq=amide+bioisosteres&source=bl&ots=6eR219wP1Q&sig=ACfU3U3t-u7v5jc6Lg2D2RLuMWg91tuxLg&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQjqARAD

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Bioisosteres in Medicinal Chemistry Page 38 Google Books Result

books.google.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

These compounds exemplify the problems outlined above with two amide groups and a sulfonamide (plus a carboxylic acid) Molecular modeling indicated that  - Information from books.google.com

Information accuracy 100%
Amide bioisosteres information was found here: https://books.google.com/books?id=jEbExXdNEwwC&pg=SA3-PA8&lpg=SA3-PA8&dq=amide+bioisosteres&source=bl&ots=gxrMhd_SDd&sig=ACfU3U3pyp8DyMzjcdigAxyomO7BtJxHHg&hl=en&sa=X&ved=2ahUKEwi0pcv4_vH0AhV763MBHQV_CscQ6AF6BQjkARAD

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Microbial proteasomes as drug targets PLOS

journals.plos.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

In order to improve the pharmacokinetic properties of DPLG2 the Cterminal amide was replaced with its bioisosteres phenylimidazole [45] - Information from journals.plos.org

Information accuracy 100%
Amide bioisosteres information was found here: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010058

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Publications The Knowles Group

knowleslab.princeton.edu

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Understanding Chemoselectivity in ProtonCoupled Electron Transfer: A Kinetic Study of Amide and Thiol Activation Guanqi Qiu Robert R Knowles - Information from knowleslab.princeton.edu

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Amide bioisosteres information was found here: https://knowleslab.princeton.edu/publications/

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Pharmacokinetics in Modern Drug Design Medicinal Chemistry

pharmafactz.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Esters and amides are major groups of carrierlinked prodrugs Bioisosteres also allow for the development of “metoo” drugs - Information from pharmafactz.com

Information accuracy 100%
Amide bioisosteres information was found here: https://pharmafactz.com/drug-design-the-complete-pharmacokinetics-guide/

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AMIDE: a Medical Image Data Analysis Tool

amide.sourceforge.net

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

AMIDE is a competely free tool for viewing analyzing and registering volumetric medical imaging data sets Its been written on top of GTK+  - Information from amide.sourceforge.net

Information accuracy 100%
Amide bioisosteres information was found here: http://amide.sourceforge.net/

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Current strategies for the design of PROTAC linkers: a critical

www.explorationpub.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

[65] 20 was reacted with DSG to install an amidelinked alkyl linker The product 21 was then reacted with the E3binding pentapeptide sequence to displace  - Information from www.explorationpub.com

Information accuracy 100%
Amide bioisosteres information was found here: https://www.explorationpub.com/Journals/etat/Article/100218

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Amide: Definition Structure & Formation Studycom

study.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

In chemistry amides are compounds that contain nitrogen atoms Learn more about the definition structure and formation of amides  - Information from study.com

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Amide bioisosteres information was found here: https://study.com/academy/lesson/amide-definition-structure-formation.html

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Properties of Amides YouTube

www.youtube.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

- Information from www.youtube.com

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Amide bioisosteres information was found here: https://www.youtube.com/watch?v=b_1GoxLmDV4

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Amines and Amides Chemistry for Majors Lumen Learning

courses.lumenlearning.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Amines are molecules that contain carbonnitrogen bonds The nitrogen atom in an amine has a lone pair of electrons and three bonds to other atoms  - Information from courses.lumenlearning.com

Information accuracy 100%
Amide bioisosteres information was found here: https://courses.lumenlearning.com/chemistryformajors/chapter/amines-and-amides/

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Preparation of amides using DCC (video) Khan Academy

www.khanacademy.org

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

- Information from www.khanacademy.org

Information accuracy 100%
Amide bioisosteres information was found here: https://www.khanacademy.org/science/organic-chemistry/carboxylic-acids-derivatives/reactions-carboxylic-jay/v/preparation-of-amides-using-dcc

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Amide Biochemistry Flashcards Draw it to Know it

www.drawittoknowit.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

Amide Functional Group • The nitrogen variant of an ester A C bonded to a hydrogen doublebonded to an O singlebonded to an N which is also bound to  - Information from www.drawittoknowit.com

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Test for Amide Group PraxiLabs Facebook

www.facebook.com

Author: openj-gate.com ~ Tags: Amide, bioisosteres ~ Date: 2023/01/28

- Information from www.facebook.com

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Amide bioisosteres information was found here: https://www.facebook.com/praxiLabs/videos/test-for-amide-group/1214795435353704/

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